520-36-5 Apigenin C15H10O5
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Apigenin Basic information |
Product Name: | Apigenin |
Synonyms: | APIGENIN;CHAMOMILE;4',5,7-TRIHYDROXYFLAVONE;4,5,7-TRIHYDROXYFLAVONE;4',5,7-TRIHYROXYFLAVONE;5,7,4'-TRIHYDROXYFLAVONE;5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE;7,4',5-TRIHYDROXYFLAVONE |
CAS: | 520-36-5 |
MF: | C15H10O5 |
MW: | 270.24 |
EINECS: | 208-292-3 |
Product Categories: | Tri-substituted Flavones;Biochemistry;Flavonoids;Natural Plant Extract;Inhibitors;Protein Kinase;Signalling;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Plant extract |
Mol File: | 520-36-5.mol |
Apigenin Chemical Properties |
mp | >300 °C(lit.) |
storage temp. | −20°C |
solubility | DMSO: 27 mg/mL |
form | powder |
color | yellow |
Merck | 14,730 |
BRN | 262620 |
CAS DataBase Reference | 520-36-5(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
RTECS | LK9276000 |
F | 10 |
HS Code | 29329985 |
Hazardous Substances Data | 520-36-5(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
SigmaAldrich | English |
ALFA | English |
Apigenin Usage And Synthesis |
Chemical Properties | Pale Yellow Crystalline Solid |
Usage | antispasmodic, antineoplastic, topoisomerase I inhibitor |
Usage | Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tum or cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap juntion intracellular communication in liver cells. |
Biological Activity | Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC 50 values are 59.44 and 31.15 μ M at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo . |
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