- Min.Order :1 Kilogram
- Purity: 99.0%Min
- Payment Terms : L/C,D/A,D/P,T/T,Other
Keywords
18883-66-4 Streptozotocin Streptozocin
Quick Details
- Appearance:off-white to pale yellow crystalline powder
- Application: For Organic Synthesis use
- PackAge:IN 25kg drums
- ProductionCapacity:10|Metric Ton|Month
- Storage:Room Temperature
- Transportation:As Per MSDS
Superiority:
| Streptozocin Basic information |
| Product Name: | Streptozocin |
| Synonyms: | N-(METHYLNITROSOCARBAMOYL)-A-D-GLUCOSAMINE;N-(METHYLNITROSOCARBAMOYL)-ALPHA-D-GLUCOSAMINE;N-(METHYLNITROSOCARBAMOYL)-ALPHA-GLUCOSAMINE;STZ;STREPTOZOCIN;STREPTOZOTOCIN;STR;ZANOSAR |
| CAS: | 18883-66-4 |
| MF: | C8H15N3O7 |
| MW: | 265.22 |
| EINECS: | 242-646-8 |
| Product Categories: | Active Pharmaceutical Ingredients;Antibiotic Explorer;Peptide Synthesis/Antibiotics;ZANOSAR;antibiotic |
| Mol File: | 18883-66-4.mol |
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Details:
| Streptozocin Chemical Properties |
| mp | 121 °C (dec.)(lit.) |
| storage temp. | −20°C |
| Water Solubility | soluble |
| Merck | 13,8912 |
| EPA Substance Registry System | D-Glucose, 2-deoxy-2-[[(methylnitrosoamino) carbonyl]amino]-(18883-66-4) |
| Safety Information |
| Hazard Codes | Xn,T |
| Risk Statements | 40-61-46-45-22-20/21/22 |
| Safety Statements | 36/37-53-45-36-22 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | LZ5775000 |
| F | 3-10-21 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Hazardous Substances Data | 18883-66-4(Hazardous Substances Data) |
| Streptozocin Usage And Synthesis |
| Chemical Properties | off-white to pale yellow crystalline powder |
| Usage | antineoplastic, alkylating agent |
| Usage | Streptozotocin is used in the treatment metastatic cancer of the pancreatic islet cells. Streptozotocin has a highlrisk of toxicity and is generally limited to cancers that are inoperable. |
| Usage | Streptozotocin is an unusual aminoglycoside containing a nitrosoamino group produced by Streptomyces achromogenes and discovered in 1959 as an antibiotic. The nitrosoamino group enables the metabolite to act as a nitric oxide (NO) donor. NO is an important messenger molecule involved in many physiological and pathological processes in the body. Streptozotocin is also widely used to induce diabetes in rodent models by inhibition of β-cell O-GlcNAcase. |
| Usage | somatostatin octapeptide analog |
| General Description | Off-white powder. Melting point 115°C. Used as an anti-cancer drug. Carcinogenic. |
| Air & Water Reactions | Water soluble. |
| Reactivity Profile | [D-GLUCOSE, 2-DEOXY-2-[[(METHYLNITROSOAMINO)-CARBONYL]AMINO] is weakly basic. Reacts exothermically with acids. Reacts with both strong oxidizing agents and strong reducing agents. |
| Biological Activity | Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β -cells in vivo . |
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