Add time:07/18/2019         Source:sciencedirect.com

A new and highly efficient method for the synthesis of 4-(benzimidazol-2-yl)quinolin-2(1H)-ones via the rearrangement of spiroquinoxalinones in moderate-to-excellent yields has been developed. The rearrangement represents a facile approach to medicinally important biheterocyclic compounds. Compared to other methods, the present protocol has a number of advantages such as – cost-effectiveness, avoidance of difficult of access quinolin-2-one and benzimidazole derivatives as reaction partners, and easy accessibility of starting materials, making it a highly practical approach to access various 4-(benzimidazol-2-yl)quinolin-2(1H)-ones.

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