A new and efficient synthesis of imidazo[1,5-a] pyridine derivatives by a tandem aza-Wittig / electrocyclic ring closure of N-vinylic phosphazenes-Science-Chemical Encyclopedia-lookchem

A new and efficient synthesis of imidazo[1,5-a] pyridine derivatives by a tandem aza-Wittig / electrocyclic ring closure of N-vinylic phosphazenes
Add time:07/22/2019 Source:sciencedirect.com

Imidazo[1,5-a]pyridines 1 are prepared by reaction of N-vinylic phosphazene 3, obtained from phosphorus ylide 5 and 2-cyanopyridine 4, with aldehydes. Formation of fused heterocycles 1 can be explained through aza-Wittig reaction of phosphazene 3, followed by 1,5-electrocyclic ring closure of the resulting aldimines 2. Phosphazene 3 undergoes pyrido annelation by reaction with Diethyl Ketomalonate to give isoquinoline derivative 9.

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