Add time:07/13/2019 Source:sciencedirect.com
The methyl 4-(diethoxymethyl)-3-(pyridin-3-yl)isoxazole-5-carboxylate obtained by domino 1,3-dipolar cycloaddition and elimination starting of pyridine-3-nitrile oxide and methyl 4,4-diethoxy-3-p-tolylsulfinylbut-2-enoate is a convenient scaffold for the synthesis of other new highly functionalised 3-pyridin-3-ylisoxazoles-5-carboxylic acid derivatives and isoxazole-annulated heterocycles.
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