Add time:07/18/2019         Source:sciencedirect.com

The lithium salts of the conjugated bases of 4-methoxy- and 4-acetylamino-2(1H)-pyrimidinones 1–3 undergo highly chemoselective N1-methylation or ethylation when treated with methyl- or ethylsulfate (hard electrophiles) in dry dioxane, while the use of DMF as solvent results in competitive O2-alkylation. Potassium salts of the same bases in DMF undergo prevalent O2-attack. Under the same conditions, a similar but less chemoselective behaviour is observed in alkylation of thymine and uracil, where some N3-attack occurs. This can be rationalised in terms of the HSAB principle.

We also recommend Trading Suppliers and Manufacturers of 1-O-Methyl-3-(acetylamino)-4-O-acetyl-2,3,6-trideoxy-α-L-lyxo-hexopyranose (cas 18981-63-0). Pls Click Website Link as below: cas 18981-63-0 suppliers