Add time:07/12/2019 Source:sciencedirect.com
A core building block 3 for (2 S,3 R,4 S,5 S,6 S,11 E)-3-amino-6-methyl-12-(4-methoxyphenyl)-2,4,5-trihydroxydodec- 11-enoic acid (2, AMMTD) has been efficiently synthesized using the Sharpless asymmetric dihydroxylation and the Dondoni's furan addition to a nitrone derivative as key steps. The 2-furyl group has been used as the carboxyl synthon. © 1997 Elsevier Science Ltd.
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