Add time:07/21/2019         Source:sciencedirect.com

The synthesis of a potent carcinogen, N-nitroso-N-methylaniline, employing a bis(dimethylglyoximato)cobaltate template is described. Carbon bonded N-methyleneaniline adducts of cobaloxime with pyridine, NO-2 or CN- in the basal (sixth) coordination position of the cobalt atom were prepared and isolated. These cobaloxime methyleneaniline adducts were found to readily undergo nitrosation when treated with nitrous acid. The resulting N-nitrosamine adducts were characterized by IR, NMR and mass spectroscopy. Interesting trans effects of the basal substituents are noted. Final template reaction products were identified by thermal degradation and chemical cleavage with Cr2+.

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