Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors-Science-Chemical Encyclopedia-lookchem

Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors
Add time:07/20/2019 Source:sciencedirect.com

Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [η6-3-(dipropylamino)chroman]Cr(CO)3. Several of the compounds have high affinity for 5-HT1a receptors whereas the affinity for D2a receptors is lower, the 8-arylated derivatives being slightly more potent than the 8-aroylated analogues.

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