Add time:07/21/2019         Source:sciencedirect.com

The extent of the hepatotoxic action of N-hydroxy-2-acetylaminofluorene in the rat was determined by following changes in histochemistry, and the activities of glutamate-oxaloacetate transaminase (EC 2.6.1.1) and glutamate-pyruvate transaminase (EC 2.6.1.2) in serum. Administration of N-hydroxy-2-acetylaminofluorene (120 μmol/kg i.v.) cased a periportal (zone I) necrosis which was accompanied by a large increase in glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase activity in serum. Treatment of rats with pentachlorophenol and 2, 6-dichloro-4-nitrophenol, known inhibitors of NO-sulfation, 45 min before the administration of N-hydroxy-2-acetylaminofluorene, completely prevented the hepatotoxic effects of this carcinogenic hydroxamic acid. Therefore, it is concluded that NO-sulfation is responsible for the hepatotoxic action of N-hydroxy-2-acetylaminofluorene.

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