Add time:07/21/2019         Source:sciencedirect.com

The colon electromyogram was recorded in vitro from the proximal colon during exposure to sodium ricinoleate and sodium oleate at 5 × 10− 9 to 10− 5 M. Records were read for the proportion of time of congruence of slow waves, for slow wave frequency, for slow wave velocity, and for the incidence of spike potentials. Also, the electrical activity of the circular muscle was recorded in the sucrose gap during exposure to sodium ricinoleate, seeking effects of the agents on slow wave amplitude. Ricinoleate, but not oleate, reduced the proportion of time when slow waves were congruent. This dose-related effect represents the excitation of ectopic pacemakers. Frequency and velocity were not affected. Ricinoleate slightly reduced amplitude at very high concentrations. The effect on congruence is like that seen previously in association with spontaneous and castor oil-induced diarrhea in cats.

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