Add time:07/27/2019         Source:sciencedirect.com

An improved method for the synthesis of 3α,7α-dihydroxy-5β-chol estan-26-oic acid and 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid is described. The method involves an Arndt-Eistert rearrangement of the corresponding diazoketone obtained by the action of diazoethane on 3α, 7α-diformyloxy-5β-cholane-24-carboxylic or 3α,7α, 12α-triformyloxy-5β-cholane-24-carboxylic acid chloride. The products are obtained in good yield and no isomeric 27-nor-24-methyl acid contaminants are formed as encountered in the commonly employed Kolbe synthesis.

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