Add time:07/23/2019         Source:sciencedirect.com

A series of novel phenol ether derivatives were designed, synthesized, and evaluated as non-covalent proteasome inhibitors. Most compounds exhibited moderate to excellent proteasome inhibitory activity. In particular, compound 18x proved to be the most potent compound (chymotrypsin-like: IC50 = 49 nM), exhibiting a 2-fold higher potency compared to the reported PI-1840. Besides, compound 18x exhibited excellent metabolic stability and selective anti-proliferative activity against solid cancer cell lines including HepG2 and HGC27, providing incentive for the further development as a potential anticancer agent against solid cancers.

We also recommend Trading Suppliers and Manufacturers of 4-(4-BROMOPHENOXY)PHENOL (cas 13320-48-4). Pls Click Website Link as below: cas 13320-48-4 suppliers