Add time:07/27/2019         Source:sciencedirect.com

SummaryDiethyl pyrocarbonate (cas 1609-47-8), a compound extensively used as a nuclease inhibitor, reacts with low molecular weight RNA and forms products which are less precipitable with certain precipitating reagents than untreated RNA. This phenomenon, erroneously interpreted by Wiegers and Hilz (Biochem. Biophys. Res. Commun. 44 (1971) 513) as degradation of RNA by diethyl pyrocarbonate, is now shown to be due to increased solubility of the treated low molecular weight RNA in precipitating reagents. This conclusion is based on (a) unaltered sedimentation pattern, (b) unchanged content in dialyzable fragments and (c) identical chain length of diethyl pyrocarbonate-treated RNA as compared to the untreated control.

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