Add time:07/22/2019 Source:sciencedirect.com
Ethyl 3-iodo-4,4,4-trifluoro-2(Z)-butenoate (2) was regio- and stereo-specific prepared from ethyl 4,4,4-trifluoro-2-butynote (1). The Sonogashira reaction of 2 with terminal alkynes afforded the (2Z)-en-4-ynoic acid derivatives containing trifluoromethyl group (4). © 1997 Elsevier Science Ltd.
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