Add time:07/21/2019 Source:sciencedirect.com
A series of hydroxamic acid derivatives of peptides related to fragments of substance P (SP) were synthesized. Methyl, ethyl or N-hydroxy-succinimide ester precursors of the desired peptides were prepared by using classical peptide synthesis methodology and these were reacted with excess hydroxylamine in either ethanol or N,N-dimethylformamide. The products were characterized by chromatographic methods, amino acid analysis and fast atom bombardment mass spectrometry. The inhibition of the degradation of the radiolabelled substrate desamino-[3-125I-tyrosyl5]SP(5–11) ([(125I)BH5]SP(5–11)) by these compounds in rat hypothalamus preparations was determined. The most potent inhibitors found were Boc-Phe-Phe-Phe-NHOH (12d, IC50 = 4 μM), Boc-Phe-Phe-Trp-NHOH (9, IC50 = 5 μM) and desamino-Tyr-Phe-Phe-Gly-NHOH (22, IC50 = 1.8 μM). A model describing the interaction of these compounds with the active site is proposed.
We also recommend Trading Suppliers and Manufacturers of BOC-P-IODO-DL-PHE-OH (cas 103882-09-3). Pls Click Website Link as below: cas 103882-09-3 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View