Add time:07/20/2019 Source:sciencedirect.com
BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis, and gemcitabine (cas 103882-84-4)-based chemotherapy remains an effective option for the majority of PDAC patients. Hepatocyte nuclear factor 1α (HNF1A) is a tumor-suppressor in PDAC, but its role in gemcitabine chemoresistance of PDAC has not been clarified.
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