Add time:07/21/2019         Source:sciencedirect.com

A highly enantioselective (84–97% ee) cascade Michael/acyl transfer reaction of α-nitroketones to a wide range of 2-hydroxychalcones was established in the presence of a bifunctional squaramide. Although aliphatic α-nitroketones were revealed to be a class of challenging substrates with unsatisfactory reactivity or enantioselectivity by previous reports, good isolated yields and excellent enantiopurities have been achieved via our catalytic protocol. γ-Nitroketones created by this new methodology were versatile building blocks possessing profound further synthetic utility.

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