Add time:07/20/2019         Source:sciencedirect.com

Publisher SummaryThis chapter reviews that adrenochrome (l), the red oxidation product of adrenaline (2) is the best known member of the family of red to violet coloured indoline-5,6-quinones, known as the aminochromes, which are readily obtained on oxidation of the corresponding catecholamines. The color reactions resulting from the oxidation of adrenaline and related catecholamines formed the basis of early qualitative and quantitative assay procedures for adrenaline. The characteristic yellow-green fluorescence, which develops rapidly when alkaline solutions of adrenaline are allowed to stand in air, and this, has become the basis of one of the most widely used methods for the estimation of catecholamines —that is, the “lutin” or “trihydroxyindole” method. The adrenochrome was proposed for the unstable red crystalline product obtained on enzymatic oxidation of adrenaline. Thus, the product responsible for the violet chromogen utilised in one of the original adrenaline assay procedures, was only isolated and characterised. Progress in the physiological, pharmacological and psychopharmacological significance of these compounds has been discussed.

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