Add time:07/11/2019         Source:sciencedirect.com

Resolution of 1-(4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol has been achieved by ethanol enantioselective lipase-catalysed alcoholysis, hydrolysis and acylation. Although a good enantioselectivity was observed in the three reactions, the best results were obtained by hydrolysis. This α-bromohydrin is an intermediate in the synthesis of a new adrenergic agent.

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