Add time:07/20/2019         Source:sciencedirect.com

The double Michael addition of benzylamine to 3-alkyl-2,7-cyclooctadienones, followed by hydrogenolysis, affords bridgehead substituted 9-azabicyclo[3.3.1]nonan-3-ones. Use of (+)-α-methylbenzylamine in the addition leads to mixtures of diastereomeric adducts in unequal amounts. Although the degree of asymmetric induction is low (10–20% ee), the diastereonomers can be easily separated, affording pure enantiomeric forms of the ladybug alkaloid adaline 1 and the Euphorbia alkaloid 3.

We also recommend Trading Suppliers and Manufacturers of 1-BROMOPENTANE-D11 (cas 126840-21-9). Pls Click Website Link as below: cas 126840-21-9 suppliers