Add time:07/20/2019         Source:sciencedirect.com

Some N-[(N-benzoyldehydrophenylalalnyl)glycinyl/cysteinyl]-N,N′-dicyclohexylurea analogs (3a–3o) were synthesized by conjugating different substituted N-benzoyldehydrophenylalanyl glycines/cysteines (differing substitutions on benzylidene ring) and dicyclohexyl carbodiimide (DCC) using base as a catalyst. The synthesized compounds were characterized and evaluated for biological activities. Compounds 3a and 3h with unsubstituted dehydrophenylalanyl glycinyl/cysteinyl moiety exhibited moderate anti-inflammatory and analgesic activities. Compound 3j bearing 4-hydroxy substitution on benzylidene ring of dehydrophenylalanyl cysteinyl moiety displayed potent antimicrobial and antioxidant activities. The results obtained from docking studies on compound 3j with penicillin binding protein and protease supported the results.

We also recommend Trading Suppliers and Manufacturers of N(epsilon)-(diazotrifluoroethyl)benzoyl-Lys(8)-cyclosporin (cas 126871-92-9). Pls Click Website Link as below: cas 126871-92-9 suppliers