Add time:07/20/2019         Source:sciencedirect.com

The reaction of different chloromethyl ethers 1 with an excess of lithium powder and a catalytic amount of 4,4′-di-tert-butylbiphenyl (2.5 mol %) in THF at 0 °C leads to the corresponding α-lithiomethyl ether intermediates, through a chlorine–lithium exchange, which spontaneously undergo a clean [1,2]-Wittig rearrangement affording the expected homobenzylic alcohols 2. This is the first version of this rearrangement starting from easily available chloromethyl ethers.

We also recommend Trading Suppliers and Manufacturers of 1-(chloromethyl)-4-(phenylmethyl)benzene (cas 14297-39-3). Pls Click Website Link as below: cas 14297-39-3 suppliers