Add time:07/23/2019         Source:sciencedirect.com

Bifunctional, acetyl-protected, azido glucuronic and galacturonic acid derivatives were coupled via the carboxylic acid moiety to amine- and hydroxyl-containing side chains of the natural amino acids lysine and serine or via the N-terminus of the amino acids leucine, methionine and glutamine. The glycosylated amino acids were then functionalized via the free azido moiety to produce the corresponding anomeric triazole derivatives. This approach enables the dual glycosylation and functionalization of a range of native amino acids in high yields.

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