Add time:07/22/2019         Source:sciencedirect.com

A study was made of the uterotonic, antidiuretic and pressor activities and the effect on the isolated mammary gland of 6 deamino-oxytocin analogues not containing a disulphide bond: [1,6-α-deaminocystathionine] -oxytocin (deamino-carba1-oxytocin, Car-1 -OT), [6,1-β-deaminocystathionine] -oxytocin (deamino-carba6-oxytocin; Car-6-OT), [1,6-α-aminosuberic acid] -oxytocin (deamino-dicarba-oxytocin; Asub-OT), [1,6-deaminolanthionine] -oxytocin (Lan-OT), [1,6-α-aminopimelic acid] -oxytocin (Apim-OT), and [1,6-deaminohomolanthionine] -oxytocin (Hlan-OT). The values of biological activity obtained in the individual tests show that the presence of the disulphide bridge in the hormone molecule is not a prerequisite for the interaction of oxytocin with the receptors. The carba analogues of deamino-oxytocin with a modified ring size have all in all decreased activity with the exception of the effect of Hlan-OT on the mammary gland where this analogue has the highest activity of all the compounds tested.

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