Add time:07/20/2019         Source:sciencedirect.com

In the present study, we synthesized novel benzimidazole–silver(I) complexes (2a–d) by the interaction of 1-benzyl-3H-benzimidazolium p-toluenesulfonate derivatives (1a–d) and Ag2O in order to investigate their anticancer properties. All the salts and complexes were fully characterized by 1H NMR, 13C NMR, IR and LC–MS spectroscopic techniques, elemental analysis and single crystal X-ray crystallography. Cytotoxic effects of compounds were investigated by MTT test against human colorectal (Caco-2), breast (MCF-7) cancer cell lines and non cancer mouse fibroblast (L-929) cell lines. All the complexes performed more cytotoxicity than cisplatin against Caco-2 cell lines while they were not active against MCF-7 in the treatment concentrations. Among the complexes, 2d which contains chlorine at 2-position of benzyl was found out as most active but not selective for non cancer L-929 cell lines. The complex 2b which contains methyl instead of chlorine at 2d showed approximately equal cytotoxicity as cisplatin against L-929 cell lines while this complex was twofold active than cisplatin against Caco-2 cell lines. These findings suggest that complex 2b is a promising candidate for treatment of colorectal cancer.

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