Add time:07/22/2019         Source:sciencedirect.com

A methodology for the lithiation of pyrimidine (1a) was developed and used for the synthesis of pyrimidylselenium compounds. The procedure involved prior complexation of 1a with 2.2 equiv. of BF3·Et2O followed by a reaction with LDA or LTMP. The pyrazinylselenium derivatives were synthesized from the direct lithiation of pyrazine (1b) as the BF3-directed lithiation failed to give the desired products. All the synthesized compounds were characterized by elemental analysis, NMR (1H and 13C) and Mass spectroscopy. In addition, 2,5-bis(methylselenenyl)pyrazine (9b) was characterized by single crystal X-ray crystallography.

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