Add time:07/22/2019         Source:sciencedirect.com

An efficient synthetic protocol affording symmetrical 1,2-bis(pyridine-2/3/4-yl)methyldiselanes from pyridine-2/3/4-carbaldehyde in high yields at room temperature, without using highly toxic hydrogen selenide, has been developed. The synthesis involves the reductive selenation of pyridine-2/3/4-carbaldehyde with sodium hydrogen selenide, NaHSe in the presence of piperidine hydrochloride followed by NaBH4 reduction under mild conditions. Primary screening of the anti-proliferative activity of the newly synthesized compounds against several mammalian cell lines and pathogenic strains has been carried out. The crystal structure of 1,2-bis(pyridine-3-yl)methyldiselane has been established by X-ray diffraction analysis.

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