Add time:07/23/2019         Source:sciencedirect.com

We devised a simple and effective purification for the microdetermination of prostaglandin B1 (PGB1), a metabolite of PGE1. [180]PGB1 was synthesized by the repeated base-catalyzed hydrolysis of methyl ester derivatives in H2180, to obtain an internal standard for the gas chromatography/selected ion monitoring (GC/SIM) of PGB1. The methyl ester-methoxime-dimethylisopropylsilyl ether derivative was prepared, then GCISIM was carried out by monitoring the ion at mz 448.3 for PGB1 and that at mz 452.3 for internal standard. A good linear response over the range of 10 pg to 100 ng was demonstrated. We detected PGB1 to a level of about 40 pglmL in human plasma. This method can be used to determine PGB1 in biological samples.

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