Add time:07/24/2019         Source:sciencedirect.com

A low yield synthesis of oxetanocin and its α-epimer by reaction of adenine with a protected 3-hydroxymethyl-2-chlorooxetane is described; attempts to synthesise other C-2′ alkyl analogues of oxetanocin by analogous reactions indicate a limitation of this strategy for the synthesis of oxetane nucleosides. An intermediate for the synthesis of C-nucleoside analogues of oxetanocin is reported.

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