Add time:07/20/2019         Source:sciencedirect.com

The effects of organic modifier, stationary phase, hydrophobic substitution, and temperature on the group contribution values for 26 homologues and analogues of the drug fentanyl were studied. Using equations relating group contribution to molecular connectivity, it was found that hydrophobic selectivity is approximately independent of mobile phase composition for mixtures commonly employed in solvent optimization schemes based on overlapping resolution mapping. Similarly, hydrophobic selectivity was also found to be almost identical on both a silica-based Partisil 10-ODS-3 column and a polymer-based PRP-1 column under normalized time conditions. In contrast, hydrophobic selectivity was found to depend on the position of methylene substitution on the parent fentanyl molecule and the type of substituent. For all mobile phases studied there is a small decrease in group contribution values with increases in temperature.

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