Add time:07/23/2019         Source:sciencedirect.com

The equilibrium constant of ADENYLOSUCCINIC ACID (cas 19046-78-7) synthesis from guanosine triphosphate, inosine-5′-phosphate and L-aspartate was determined to be 2.9 and 10.0 in the forward and reverse directions respectively at pH 8.0 and 37°. The ΔF° of adenylosuccinic acid hydrolysis to inosine-5′-phosphate and aspartate was calculated to be -−8.6 kcal/mole. From equilibrium-exchange studies, the limitations of which are mentioned, it appears that 6-phosphoryl-inosine-5′-phosphate may be an intermediate in adenylosuccinic acid synthesis.

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