Add time:07/23/2019         Source:sciencedirect.com

IntroductionRenal transplantation is one of the best options for patients suffering from end stage renal disease (ESRD). Cyclosporine and TACROLIMUS (cas 109581-93-3) are mainly applied in immunosuppressive therapy after transplantation of liver, kidney, heart, and other organs. The used of immunosuppressant drugs improve the survival of transplanted organs and reduce organ rejection. Because of their narrow therapeutic index and significant inter-individual variability in blood concentrations, they need to monitor carefully. Therapeutic drug monitoring of tacrolimus and cyclosporine were needed to optimize the outcome in patients after renal transplantations. Maintaining the drugs levels reduce the risks of toxicity or rejection, respectively.

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