Add time:07/23/2019         Source:sciencedirect.com

Looking to the pharmacological importance of 8-hydroxyquinolines, in the present study, a novel ligand 5-((1-methyl-1,2-dihydroquinolin-4-yloxy) methyl) quinolin-8-ol (MDMQ) was synthesized by the reaction of 1-methyl-1,2-dihydroquinolin-4-ol with 5-chloromethyl- 8-hydroxyquinoline hydrochloride. Its metal complexes were also prepared with Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) salts. All the above compounds were investigated by physicochemical analysis, thermogravimetric analysis and spectroscopic techniques. In vitro antimicrobial activity of all synthesized compounds and standard drugs has been evaluated against four strains of bacteria which include two gram +ve bacteria such as Staphylococcus aureus, Bacillus megaterium and two gram −ve bacteria such as Escherichia coli, Proteus vulgaris and one fungi Aspergillus niger.

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