Add time:07/22/2019         Source:sciencedirect.com

The 3-deaza analogs of the naturally occurring adenine-based carbocyclic nucleosides aristeromycin and neplanocin possess biological properties that have not been optimized. In that direction, this paper reports the strategic placement of a fluorine atom at the C-2 and C-3 positions and a methyl at the C-3 site of the 3-deazaadenine ring of the aforementioned compounds. The synthesis and S-adenosylhomocysteine hydrolase inhibitory and antiviral properties of these targets are described. Some, but not all, compounds in this series showed significant activity toward herpes, arena, bunya, flavi, and orthomyxoviruses.

We also recommend Trading Suppliers and Manufacturers of 2-FLUORO-3-(HYDROXYMETHYL)PYRIDINE (cas 131747-55-2). Pls Click Website Link as below: cas 131747-55-2 suppliers