Add time:07/23/2019         Source:sciencedirect.com

The synthesis of 3-(2′-[18F]fluoroethyl)spiperone (1c), a radiotracer useful for imaging the brain dopamine receptor system in vivo using positron emission tomography, is described. Precursors of 1c, the functional 3-N-alkyl derivatives of spiperone (4), were prepared by the alkylation of the amide group in spiperone (2a) by 1,2-disubstituted ethanes under phase transfer conditions. A comprehensive evaluation of the reaction of the derivatives 4a–h with no-carrier-added K 18F/Kryptofix clearly indicated that the ketalized derivatives 4e–h were the choice of the precursors for 1c. The i.r., MS and NMR spectral data suggested that under phase transfer reaction conditions, the amide nitrogen was preferentially alkylated. To provide a firm basis for comparison with related analogues, an x-ray analysis was performed on a single crystal of 3-(2′-fluoroethyl)spiperone (1d). The tomographic behavior of 1c in human brain tissue was measured for more than 7 h and was consistent with the labeling of dopamine D-2 receptors.

We also recommend Trading Suppliers and Manufacturers of 3-N-(2-fluoroethyl)spiperone (cas 106114-42-5). Pls Click Website Link as below: cas 106114-42-5 suppliers