2-[18F]Fluoroethanol and 3-[18F]fluoropropanol: facile preparation, biodistribution in mice, and their application as nucleophiles in the synthesis of [18F]fluoroalkyl aryl ester and ether PET tracers-Science-Chemical Encyclopedia-lookchem

2-[18F]Fluoroethanol and 3-[18F]fluoropropanol: facile preparation, biodistribution in mice, and their application as nucleophiles in the synthesis of [18F]fluoroalkyl aryl ester and ether PET tracers
Add time:07/24/2019 Source:sciencedirect.com

Introduction2-[18F]Fluoroethoxy and 3-[18F]fluoropropoxy groups are common moieties in the structures of radiotracers used with positron emission tomography. The objectives of this study were (1) to develop an efficient one-step method for the preparation of 2-[18F]fluoroethanol (2-[18F]FEtOH) and 3-[18F]fluoropropanol (3-[18F]FPrOH); (2) to demonstrate the feasibility of using 2-[18F]FEtOH as a nucleophile for the synthesis of 2-[18F]fluoroethyl aryl esters and ethers; and (3) to determine the biodistribution profiles of 2-[18F]FEtOH and 3-[18F]FPrOH in mice.

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