Add time:07/24/2019 Source:sciencedirect.com
Perisulfakinin, a peptide with sequence similarity to gastrin and cholecystokinin, was isolated from the corpora cardiaca of the American cockroach. Its sequence was determined to be Glu-Gln-Phe H-Asp-Asp-Tyr(SO3H)-Gly-His-Met-Arg-Phe-amide. The peptide induced hindgut contractions in the same species at concentrations as low as 250 pM. A related non-sulfated peptide was also isolated and sequenced; it was found to be identical with non-sulfated leucosulfakinin II (pGlu-Ser-Asp-Asp-Tyr-Gly-His-Met-Arg-Phe-amide). This peptide did not stimulate hindgut contractions. The structures of the cockroach peptides of the leucosulfakinin family are thus much more conserved than the cockroach hypertrehalosemic hormones.
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