Add time:07/11/2019         Source:sciencedirect.com

The polymer-supported synthetic protocol for preparation of thiazolidinedione-pyrimidine hybrids was developed and applied for rapid and effective synthesis of a library of variously substituted conjugates. Reported synthetic methodology is based on easy accessible building blocks and very simple chemical operations enabling effective development of potent experimental therapeutics of this type via a combinatorial manner. Synthesized model compounds were tested for their antitubercular activity against Mycobacterium tuberculosis H37Rv, antimicrobial activity against several Gram-positive and Gram-negative strains such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Enterococcus faecalis and two fungal strains (Candida albicans and Aspergillus niger). Slight activity was found for some of them.

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