Add time:07/22/2019         Source:sciencedirect.com

Synthesis of 2-[2-hydroxy-3-(4-aryl-1-piperazinyl)propyl] derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones (8–12) is described. The chlorides used in the above synthesis can exist in two isomeric forms: chain (18–20) and cyclic (19a, 20a). The compounds 8–12 exhibited potent analgesic activity which was superior than that of acetylsalicylic acid in two different tests. Most of the investigated imides suppressed significantly spontaneous locomotor activity in mice.

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