Add time:07/22/2019         Source:sciencedirect.com

Thermal rearrangement of 4-allyl-, 4-dimethylallyl-, and 4-propargyl-isopyrazoles proceed by [3,3]-sigmatropic processes to pyrazoles. The migration terminus is the C(3) Me group, if present, and the rearrangement is preceded by imine-enamine tautomerism. When enamine formation is not possible the rearrangment is diverted to nitrogen. Thermal rearrangements of 4-alkyl- and 4-benzyl-isopyrazoles also occur although at higher temperatures and evidence is presented suggesting [1,5]-sigmatropic processes are involved. Some pyrazolenine to pyrazole rearrangements involving migration of ester and phenyl groups are also reported.

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