Add time:07/25/2019         Source:sciencedirect.com

The skin irritating potential of sucrose laurate was studied in the normal guinea pig model. The results showed that sucrose laurate exhibited no skin irritating effect at all. The application of sucrose laurate as an excipient in hydrophilic dermal preparations was investigated, by measuring the inhibition of contact sensitivity skin reactions to dinitrofluorobenzene (DNFB), after topical application of a cyclosporin A hydrogel. The findings showed that the sucrose laurate hydrogel formulation was somewhat less effective as compared to a sucrose laurate or ethanolic solution, but still superior to a reference paraffin suspension. The sucrose laurate/cyclosporin A hydrogel significantly reduced the skinfold thickness after 24, 32, 48 and 56 h of sensitization (p < 0.01−0.001). Skin permeability experiments indicated that the sucrose laurate has some intermediate skin permeability enhancing properties. Conclusively, these findings showed that sucrose laurate is a suitable, non irritating excipient for the dermal formulation of the poorly water soluble cyclosporin A. In order to obtain an optimal sucrose laurate (trans)dermal hydrogel formulation, however, the effect of surfactant or cyclosporin A concentration and the presence or absence of occlusion must be subjected to further investigation.

We also recommend Trading Suppliers and Manufacturers of OLEYL LAURATE (cas 19149-85-0). Pls Click Website Link as below: cas 19149-85-0 suppliers