Add time:07/24/2019         Source:sciencedirect.com

A regioselective, solvent-free and catalyst-free synthesis of isoxazoles has been successfully developed under ball milling conditions. Milling the mixtures of N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds in a ball mill at a frequency of 14.6 Hz for 20–60 min afforded isoxazoles in up to 86% yields. A possible reaction mechanism leading to the formation of the observed isoxazoles is proposed.

We also recommend Trading Suppliers and Manufacturers of N-(4-BROMOPHENYL)-N-METHYLTHIOCARBAMOYL CHLORIDE (cas 10219-03-1). Pls Click Website Link as below: cas 10219-03-1 suppliers