Add time:07/23/2019         Source:sciencedirect.com

Summary[(Nα-Me)Leu7]LRF, (pGlu-His-Trp-Ser-Tyr-Gly-(Nα-Me)Leu-Arg-Pro-Gly-NH2), and [D-Ala6,(Na-Me)Leu7]LRF, (pGlu-His-Trp-Ser-Tyr-D-Ala-(Nα-Me) Leu-Arg-Pro-Gly-NH2), were synthesized by solid-phase methodology. The peptides were assayed by the in vitro system against LRF and found to have ca. 102% and 560% the potency of LRF respectively. The biological results are interpreted in terms of the conformational aspects of LRF.

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