Add time:07/25/2019         Source:sciencedirect.com

Summary3-Methylpiperidine derivatives of 1-[1-(2-thienyl)cyclohexyl]piperidine (TCP) and l-[1-(2-benzo[b]thiophenyl)cyclohexyl] piperidine (BTCP) were obtained in their racemic and homochiral forms. They have been tested for their affinity for the PCP receptor labeled with [3H]TCP and for the dopamine transporter labeled with [3H]BTCP. The homochiral TCP derivative (+)-R displayed a very high affinity (5.2 nM) and selectivity for the PCP receptor. In contrast, the homochiral BTCP derivative (−)-S therefore of opposite configuration, displayed a very high affinity (3.5 nM) and selectivity for the dopamine transporter.

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