Enantioselective solution- and solid-phase synthesis of glutamic acid derivatives via Michael addition reactions-Science-Chemical Encyclopedia-lookchem

Enantioselective solution- and solid-phase synthesis of glutamic acid derivatives via Michael addition reactions
Add time:07/23/2019 Source:sciencedirect.com

The enantioselective conjugate addition of Schiff base ester derivatives to Michael acceptors either in solution (56–89% e.e.) or on solid-phase (34–82% e.e.) gave optically active unnatural α-amino acid derivatives. The reaction was conducted in the presence of chiral, non-racemic quaternary salts derived from the cinchona alkaloids using neutral, non-ionic phosphazene bases.

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