Add time:07/24/2019         Source:sciencedirect.com

A colorimetric assay for hydralazine hydrochloride based on the interaction of the drug with 9-methoxyacridine is described. The highly colored substituted 9-aminoacridine product shows an absorption maximum at 455 nm. Color development is affected by time of heating or standing at ambient temperature and by the quantity of acridine reagent used. The method will determine hydralazine in the 0.1–12 μg/ml range with good accuracy and precision. It can be used to analyze for hydralazine hydrochloride concentration in pharmaceutical dosage forms.

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