Add time:07/11/2019         Source:sciencedirect.com

In continuation of our research for novel human dihydroorotate dehydrogenase (hDHODH) inhibitors, herein we reported design, synthesis and pharmacological evaluation of novel substituted quinoline-2-carboxamide derivatives. Human DHODH enzyme inhibition assay was used to screen the synthesized compounds as hDHODH inhibitors. The synthesized compounds were also evaluated for their antiproliferative effects on the cancer cell lines (HEP-3B and A-375) to establish a proof as anticancer agents. The chemical structures of compounds were confirmed by 1H, 13C NMR, IR, MS and elemental analysis. The purity of compounds was also checked by HPLC analysis. Compounds with bulky groups (–OCH3, –OCF3 and –CF3) at C6-position of quinoline ring showed good activity.

We also recommend Trading Suppliers and Manufacturers of 3',4',5'-trifluorobiphenyl-2-aMine (cas 915416-45-4). Pls Click Website Link as below: cas 915416-45-4 suppliers