Add time:07/24/2019         Source:sciencedirect.com

A dose of dimethylstilbestrol (cas 13366-36-4), which is anti-estrogenic when given as a single intravaginal injection, produces all the vaginal changes characteristic of estrogen action when given as 1 or 2 series of 10 1-hourly injections. Similar results were obtained with 16-oxo-estradiol given in 1 or 2 series of 5 2-hourly injections. It is suggested that competitive antagonists of estrogens themselves act as estrogens if they occupy receptor sites for a sufficient length of time.

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