Synthesis of 6-substituted-3-hydroxy-4(1H)-pyridinones: Oxidation-Michael addition of 3-hydroxy-4(1H)-pyridinones-Science-Chemical Encyclopedia-lookchem

Synthesis of 6-substituted-3-hydroxy-4(1H)-pyridinones: Oxidation-Michael addition of 3-hydroxy-4(1H)-pyridinones
Add time:08/01/2019 Source:sciencedirect.com

2-Alkyl-3-hydroxy-4(1H)-pyridinones can be oxidized by silver(I) oxide in alcoholic solution to give 2-alkoxy-2-alkyl-1,2dihydro-pyridine-3,4-diones, which can subsequently undergo a Michael addition with nucleophiles to give 6-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.

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